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Lactéol Fort®

About the Disease

Both acute and severe forms of diarrhea are common causes of death in developing countries, and the second most common cause of infant deaths worldwide.

In clinical practice, general practitioners and hospital doctors frequently combine rehydration treatment with an antidiarrheal drug to provide for faster recovery in acute and severe cases. Because diarrhea is commonly caused by bacterial toxins, the most common complement to rehydration tends to be a broad-spectrum antibiotic.
Broad-spectrum antibiotics, however, constitute a special issue since they are frequently misused, giving rise to the emergence of antibiotic-resistant enteropathogenic strains.

Probiotics provide a valuable and efficacious alternative to antibiotics. By exerting their benefits through several mechanisms, probiotics prevent colonization, cellular adhesion and invasion by pathogenic organisms. In so doing, they have direct antimicrobial activity and they modulate the host immune response.

About Lactéol Fort

Lactéol Fort is an efficient and safe antidiarrheal probiotic. It contains the Lactéol strain of Lactovacillus acidophilus LB from human origin, and has been prescribed worldwide for more than 30 years. PUMC Pharmaceutical has imported and marketed the product in China since early 1998, with an approved indication for the treatment of diarrheas of non-organic origin in adults, children and infants.

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Special Manufacturing Process

Heating Treatment
A special "heating treatment" process for lyophilization obtains high bacterial concentrations, which provides Lactéol Fort's sachet and capsule formulations with high concentrations of active substance.

  Sachet Capsule
Lactéol Fort
corresponding to
340 mg 170 mg
L. acidophilus LB 10 billion 5 billion
Culture medium 160 mg 80 mg

Unique Active Mechanism of Lacteol
The lactobacilli contained in Lactéol Fort are able to adhere to intestinal cells. By inhibiting the ability of pathogens to adhere to and invade these intestinal cells, Lactéol Fort acts against the infectious process of diarrhea and stops symptoms rapidly. Its mechanism of action is a natural antidiarrheal activity in symbiosis with the intestinal ecosystem.

Inhibition of adhesion of microorganisms responsible for diarrhea

Antimicrobial activity of the culture medium against extracellular and intracellular pathogenic germs

(1) Chauviere G., et al., Adhesion of human Lactobacillus strain LB to human enterocyte-like Caco-2 cells. Journal of General Microbiology. 1992, 138: 1689-1696.
(2) Chauviere G., et al., Competitive exclusion of diarrheagenic Escherichia coli (ETEC) from human enterocyte-like Caco-2 cells by heat-killed lactobacillus. FEMS Microbiology Letters. 1992, 81:213-218.
(3) Coconnier M.H., et al., Inhibition of adhesion of enteroinvasive pathogens to human intestinal Caco-2 cells by Lactobacillus acidophilus LB decreases bacterial invasion. FEMS Microbiology Letters. 1993, 110:299-306.
(4) Coconnier M.H., et al., Adhering heat-killed human Lactobacillus acidophilus, strain LB, inhibits the process of pathogenicity of diarrhoeagenic bacteria in cultured human intestinal cells. L. Diarrhoeal Dis. Res., Dec. 1993, vol.4: 235-242.
(5) Coconnier M.H., et al., Antibacterial effect of the adhearing human Lactobacillus acidophilus Strain LB. Antimicrobial Agents and Chemotherapy, May 1997, Vol. 41, No.5: 1046-1052.

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Lactéol Fort Advantages Benefits to patients
Preparation of heat-killed
Lactobacillus LB strain
No risk of translocation (contrary to living strains used as probiotics) and drug resistance Ensures a high safety of use
High content in active substance Promotes adhesion to intestinal cells and protects enterocytes from pathogenic agents Rapid action shortens treatment duration
Broad antimicrobial mechanism of action Antidiarrheal activity against diarrhea of all origins, not just bacterial Broadens efficacy against multiples types of diarrhea
Combined with antibiotherapy Coordination with antibiotic Strengthens efficacy against diarrhea of bacterial origins

1) Significantly reduces the duration of diarrhea[1]

The 73 hospitalized children (ages between 3 to 24 months) had on average greater than 8 stools per day, and the treatment was limited to 2 days. Lactéol Fort given in addition to oral rehydration reduced, with statistical significance, the duration of diarrhea, from both bacterial and viral origins.

[1] Nipat Simakachorn, et al., Clinical evaluation of the addition of lyophilized, heat-killed Lactobacillus acidophilus LB to oral rehydration therapy in the treatment of acute diarrhea in children. Journal of Pediatric Gastroenterology and Nutrition 2000, 30:68-72.

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2) Normalizes the number of stools by the first day[1]

The associated clinical symptoms disappeared in 3 patients out of 4 in an open trial carried out in 137 adults outside hospitals.
[1]Dra. Amalia Jaimes Saigado, Dr. Jose Andres Garcia Jara. Empleo de L.a. Cepa Lacteol en el tratamiento de la Diarreas Agudas Estudio Abiorto. Revista del Hospital de la mujer, 1993, vol.2. p.61-63.

Prescribing Information

Package insert (for download)

Guidelines for Clinical Use

2-4 capsules daily, in accordance with the severity of diarrhea. The dosage can increase to 6 capsules on the first day.


Number of sachets First day Following days
  1st dose 2nd dose 1st dose 2nd dose
Infants (*) 1 1 1 1
Children 1 1 1 1
Adults 2 1 1 1
Contents of sachet can be mixed with any liquid for consumption

Infants (less than 2 years): Administered in conjunction with rehydration therapy.
More than 2 years: This treatment should be completed with rehydration when needed.
The degree of rehydration and its route of administration (oral or intravenous) must be adapted to the severity of the diarrhea, and to the age and background of the patient.

Frequently Asked Questions

Q: How does Lactéol Fort ensure its high safety?
A: The active substance of Lactéol Fort contains a special, heat-killed strain of Lactobacillus acidophilus LB from human origin: the Lactéol strain.

Q: Why does Lactéol Fort have excellent stability compared with other probiotics containing living strains?
A: During the manufacturing process of Lactéol Fort, the bacteria are heat-killed in their culture medium. Therefore, the pharmacological properties of the Lactéol strain are heat-stable.

Q: Why can Lactéol Fort be used combination with antibiotics?
A: The lactobacilli contained in Lacteol Fort are heat-killed, so they do not influence the efficacy of antibiotics. They are able to adhere to the intestinal cells, then create a biofilm that protects the receptor sites from pathogenic germs.

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