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Sufentanil

Sufentanil

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Prescribing Information

Guidelines for Clinical Use

  • Balanced anesthesia
Induction of Anesthesia:
Loading doses: 0.25-2 µg/kg

Maintenance of Anesthesia:

 

Additional boli: 0.03-0.15 µg/kg

  Infusion rate: 0.2-1.5 µg/kg/h

Note: Effective plasma concentrations 0.5-3ng/ml,

  Threshold plasma concentration for ventilation < 0.2ng/ml
 

Infusion should be stoped 45 min before the end of surgery

  No bolus administration within 45 min before extubation
  • Total intravenous anesthesia (TIVA/TCI) – Combination of propofol and sufentanil; Extubation immediately after surgery
Induction of Anesthesia:

Sufentanil-TCI: Cp=2ng/ml—›
Ce=0.3ng/ml—›
Cp=0.5ng/ml.

Propofol-TCI: Cp=3-5ug/ml,"LOC",

Rocuronium: 0.6mg/kg
2min later Intubation
Before cutting bark:

Sufentanil: Cp=0.5ng/ml

Propofol: Cp=3-5ug/ml Loading doses: 0.25-2 µg/kg

Maintenance of Anesthesia:

 

TCI-TIVA
Sufentanil: Cp=0.2-0.5ng/ml;
Propofol:Cp=3-5ug/ml.

Source : Combination of Propofol and Sufentanil TCI for total intravenous anesthesia. Beijing Chao-Yang Hospital, Wu Qiwei, Yue Yun.

  • Postoperative Analgesia

Patient Controlled Intravenous Analgesia (PCIA)

  • Loading dose : 5μg (infusion after extubation) loading dose
  • Compatibility drug : Sufentanil 150μg+0.9%NS to 200ml
  • Background dose : 3ml/h 
  • Single dose : 2ml
  • Lockout time : 30min

Source: Administration doses from Southern Hospital

Patient Controlled Epidural Analgesia (PCEA)

  Chest post-op.1 Abdomen post-op. 2 gynecology post-op.1 orthopedics post-op.1
Compatibility Suf. 0.6μg/ml+0.125%Rop. Suf.0.5μg/ml+0.12%Rop Suf. 0.4μg/ml+0.125%Rop Suf. 1.25μg/ml+0.125%Rop
Loading dose 5ml ---- 5ml 5ml
Background dose 2ml/h 4ml/h 2ml/h 4ml/h
Single dose

3ml

2ml

3ml

2ml

Lockout time

30min 20min 30min 30min
Analgesia time

48h 48h 48h 48h
Total amount(ml) 135.70±21.44 203.41±22.68 134.96±23.584 199.75±5.994

1.Beijing Chao-Yang Hospital; 2. Peking University First Hospital

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