Prescribing Information
Guidelines for Clinical Use
| Induction of Anesthesia: |  | Loading doses: 0.25-2 µg/kg | Maintenance of Anesthesia: | | | Additional boli: 0.03-0.15 µg/kg | | | Infusion rate: 0.2-1.5 µg/kg/h | Note: Effective plasma concentrations 0.5-3ng/ml, | | | Threshold plasma concentration for ventilation < 0.2ng/ml | | | Infusion should be stoped 45 min before the end of surgery | | | No bolus administration within 45 min before extubation | |
- Total intravenous anesthesia (TIVA/TCI) – Combination of propofol and sufentanil; Extubation immediately after surgery
| Induction of Anesthesia: | | Sufentanil-TCI: Cp=2ng/ml—›
Ce=0.3ng/ml—›
Cp=0.5ng/ml. Propofol-TCI: Cp=3-5ug/ml,"LOC", Rocuronium: 0.6mg/kg
2min later Intubation
Before cutting bark: Sufentanil: Cp=0.5ng/ml Propofol: Cp=3-5ug/ml Loading doses: 0.25-2 µg/kg | Maintenance of Anesthesia: | | | TCI-TIVA
Sufentanil: Cp=0.2-0.5ng/ml;
Propofol:Cp=3-5ug/ml. | |
Source : Combination of Propofol and Sufentanil TCI for total intravenous anesthesia. Beijing Chao-Yang Hospital, Wu Qiwei, Yue Yun.
Patient Controlled Intravenous Analgesia (PCIA)
| - Loading dose : 5μg (infusion after extubation) loading dose
- Compatibility drug : Sufentanil 150μg+0.9%NS to 200ml
- Background dose : 3ml/h
- Single dose : 2ml
- Lockout time : 30min
| |
Source: Administration doses from Southern Hospital
Patient Controlled Epidural Analgesia (PCEA)
| Chest post-op.1 | Abdomen post-op. 2 | gynecology post-op.1 | orthopedics post-op.1 | | Compatibility | Suf. 0.6μg/ml+0.125%Rop. | Suf.0.5μg/ml+0.12%Rop | Suf. 0.4μg/ml+0.125%Rop | Suf. 1.25μg/ml+0.125%Rop | | Loading dose | 5ml | ---- | 5ml | 5ml | | Background dose | 2ml/h | 4ml/h | 2ml/h | 4ml/h | | Single dose | 3ml | 2ml | 3ml | 2ml | | Lockout time | 30min | 20min | 30min | 30min | | Analgesia time | 48h | 48h | 48h | 48h | | Total amount(ml) | 135.70±21.44 | 203.41±22.68 | 134.96±23.584 | 199.75±5.994 | |
1.Beijing Chao-Yang Hospital; 2. Peking University First Hospital
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